Endocrine Abstracts

Metabolic syndrome is an important social problem concerning a growing number of people. In different countries across Europe, its incidence is estimated at 17.4–28%. The metabolic syndrome is a constellation of risk factors for cardiovascular diseases. Hipothyreosis can additionally influence on lipid and carbohydrate disorders.The described study was a prospective, two-centre (A. Jurasz University Hospital No. 1 in Bydgoszcz, District Hospital in ...

Patients with acromegaly have 2–3 fold increased mortality from cardiovascular diseases. It is associated with elevated growth hormone (GH) levels. Alterations of acute phase proteins, observed in patients with acromegaly, could lead to increased cardiovascular mortality. There are limited data on influences of GH excess on acute phase reactants.The aim of the study was to evaluate selected acute phase proteins levels: fibrinogen and C-reactive prot...

Introduction: Calcium ions (Ca2+) play an essential role in process of correct β-cell insulin secretion. Hypocalcemia impairs insulin secretion leading to glucose metabolism disorders and insulin resistance.Case study: 62 -year old female patient with 18 years history of type 2 diabetes, treated with insulin, suspected of hypoparathyroidism, was admitted to the Department and Clinic of Endocrinology, Medical University of Lublin because o...

Pancreatic neuroendocrine tumors constitute a disease with steadily increasing prevalence worldwide in part owing to the increased detection of early stage disease. Here we present the case of a 49 year old male patient, who was admitted with clinical, laboratory and CT features of acute pancreatitis. A clear cause for the pancreatitis could not be detected. Excessive alcohol intake was reliably denied, and the patient did not take any drugs. Gallbladder and bile ducts were in...

Fluid and electrolyte disturbances are a challenging problem of inpatients, especially in those subpopulations, in whom the electrolyte imbalance is involved in the pathogenesis of the primary disease. Here we present the case of a 58 year old woman, with ongoing alcohol abuse on a daily basis, who was admitted with progressive fatigue and dysphagia. At the admission BMI was 17.8 kg/m2, and the patient presented deficiency of vitamins A, B, and D. The diagnostic pro...

Introduction: Irisin is a newly discovered adipo-myokine, that has a significant influence on body metabolism. Available data about this peptide is still insufficient. The aim of the study is to provide some initial information about body distribution of irisin in rats.Methods: The studied group consisted of 27 10-week-old female Wistar rats, which received intraperitoneally ~0.7 mcCi of iodine-125 labeled irisin. The studied rats were divided on five su...

We have earlier shown that treatment with gonadotropin releasing hormone antagonist blocked adrenocortical tumour progression through gonadotropin suppression in inhibin α/SV40 T-antigen (inhα/Tag) transgenic (TG) mice. Hereby, we investigated the molecular mechanisms underlying the GnRH antagonist (Cetrorelix acetate; GnRH-a) treatment induced potential antitumor effects on gonadal somatic cell and adrenocortical tumors in vivo and in vitro. In...

Pituitary tumor is a rare endocrine disorder. In the majority of cases, they are secreting prolactin and/or GH. Pituitary metastatic tumors are localized more often in the nervous than adenomatous hypophysis. Lung, breast and large intestine cancers metastases are found in the pituitary in the most cases. They cause hypopituitarism and local complications. The most often complications found are an optic nerve chiasm pressure or infiltration with a visual field loss, cavernous ...

Leptin, adiponectin and resistin play an essential role in regulation of body mass, which is controlled by thyroid hormones levels.The aim of the study was to evaluate leptin, adiponectin and resistin levels in young patients with Graves’ disease and in children with Hashimoto’s thyroiditis.The study group formed 78 patients suffering from Graves’ disease (30 girls and 2 boys; aged from 6 to 21- mean 15.2 years) and ...

Adrenocortical carcinoma (ACC) is a rare neoplasm with poor prognosis. Patients can present signs of hormone excess: virilisation, Cusging’s syndrome or only enlarged abdominal mass. Incidentally ACC can be also detected in the ultrasonography. Some of ‘non-hypersecretory’ ACCs can produce non-bioactive hormones steroid precursors or not very big amount of them and sometimes patients present subclinical Cushing’s symptoms. Surgery and adjuvant radiotherapy ...